Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer

Viral vector and lipid nanoparticle based gene delivery have limitations around spatiotemporal control, transgene packaging size, and vector immune reactivity, compromising translation of nucleic acid (NA) therapeutics. In the emerging field of DNA and particularly RNA‐based gene therapies, vector‐f...

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Veröffentlicht in:	Advanced science 2025-01, Vol.12 (3), p.e2406545-n/a
Hauptverfasser:	Pinyon, Jeremy L., Jonquieres, Georg, Mow, Stephen L., Abed, Amr Al, Lai, Keng‐Yin, Manoharan, Mathumathi, Crawford, Edward N., Xue, Stanley H., Smith‐Moore, Sarah, Caproni, Lisa J., Milsom, Sarah, Klugmann, Matthias, Lovell, Nigel H., Housley, Gary D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioluminescence DNA - genetics DNA and RNA vaccines Efficiency Electric Conductivity electric field focusing Electric fields Electroporation - methods Gene Transfer Techniques Genetic Therapy - methods Mice Muscle, Skeletal - metabolism Musculoskeletal system nonviral gene therapy nucleic acid electrotransfer precision gene delivery platform Proteins RNA, Messenger - administration & dosage RNA, Messenger - genetics Vaccines
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