Modulating Treg cell activity in prostate cancer via chitosan nanoparticles loaded with si-BATF/PRDM1

•Nanoparticle-based therapy offers a targeted approach for prostate cancer treatment.•Chitosan nanoparticles deliver siRNA to inhibit BATF and PRDM1 in Treg cells.•Inhibition of BATF and PRDM1 suppresses prostate cancer growth and metastasis.•BATF and PRDM1 are pivotal targets in nanoparticle-mediat...

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Veröffentlicht in:	International immunopharmacology 2025-01, Vol.144, p.113445, Article 113445
Hauptverfasser:	Zhao, ZhanPeng, An, RunZe, Tang, WenMin, Chen, JiaHua, Xu, Rui, Kan, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BATF Cell Line, Tumor Chitosan Chitosan - chemistry Humans Male Mice Nanoparticles Nanoparticles - chemistry PRDM1 Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy RNA, Small Interfering - genetics T-Lymphocytes, Regulatory - immunology Treg cells
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