mRNA compartmentalization via multimodule DNA nanostructure assembly augments the immunogenicity and efficacy of cancer mRNA vaccine

Messenger RNA (mRNA) vaccine has fueled a great hope for cancer immunotherapy. However, low immunogenicity, caused by inefficient mRNA expression and weak immune stimulation, hampers the efficacy of mRNA vaccines. Here, we present an mRNA compartmentalization-based cancer vaccine, comprising a multi...

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Veröffentlicht in:	Science advances 2024-11, Vol.10 (47), p.eadp3680
Hauptverfasser:	Guo, Xiaocui, Guo, Mengyu, Cai, Rong, Hu, Mingdi, Rao, Le, Su, Wen, Liu, He, Gao, Fene, Zhang, Xiaoyu, Liu, Jing, Chen, Chunying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Vaccines - administration & dosage Cancer Vaccines - immunology Cell Line, Tumor Dendritic Cells - immunology DNA - chemistry DNA - immunology Humans Immunogenicity, Vaccine Immunotherapy - methods Mice mRNA Vaccines Nanostructures - chemistry Neoplasms - immunology Neoplasms - therapy Oligodeoxyribonucleotides RNA, Messenger - genetics RNA, Messenger - immunology
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