Utilization of kidneys from tuberculosis-infected donors in renal transplantation: A case report

Tuberculosis (TB) infection in solid organ transplantation is a non-negligible problem in TB-endemic countries, and none of the existing guidelines recommend using organs from individuals with active TB infections. Here, we describe three cases of utilization of kidneys from TB-infected donors in re...

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Veröffentlicht in:Transplant immunology 2025-02, Vol.88, p.102151, Article 102151
Hauptverfasser: Yifan, Lu, Yiting, Liu, Jiangqiao, Zhou, Tao, Qiu
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Sprache:eng
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Zusammenfassung:Tuberculosis (TB) infection in solid organ transplantation is a non-negligible problem in TB-endemic countries, and none of the existing guidelines recommend using organs from individuals with active TB infections. Here, we describe three cases of utilization of kidneys from TB-infected donors in renal transplantation at our center, two of whom had active TB. In these three cases, all recipients had good graft function and negative TST results during the 1–4 year follow-up period. This case report emphasizes the critical role of early diagnosis, prophylaxis and treatment of TB in renal transplantation, demonstrates the potential for utilizing kidneys from donors with active TB, and opens up a new possibilities for solid organ transplantation. •Early diagnosis, prophylaxis and treatment of tuberculosis are crucial for solid organ transplantation.•Tuberculosis screening is required for all solid organ donors (living and deceased).•Active tuberculosis infection in the donor is a contraindication for organ transplantation.
ISSN:0966-3274
1878-5492
1878-5492
DOI:10.1016/j.trim.2024.102151