Ferroptosis-disease perils and therapeutic promise

Ferroptosis-disease perils and therapeutic promise

Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment.

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Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 2024-11, Vol.386 (6724), p.848-849
Hauptverfasser: Brown, Ashley R, Hirschhorn, Tal, Stockwell, Brent R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell death
Cell membranes
Damage
Ferroptosis
Ferroptosis - drug effects
Glutathione
Glutathione peroxidase
Hemochromatosis - metabolism
Hemochromatosis - therapy
Humans
Iron
Iron - metabolism
Lipid metabolism
Lipid peroxidation
Lipids
Mortality
Neoplasms - metabolism
Neoplasms - therapy
Neurodegeneration
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - therapy
Oxidation
Peroxidase
Polyunsaturated fatty acids
Reactive oxygen species
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Beschreibung
Zusammenfassung:Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.adn7030