Psychomotor development, emotional regulation, and executive functions in 2-years-old children after threatened preterm labour: a prospective cohort study

A threatened preterm labour (TPL) represents an adverse prenatal event with potential long-term consequences on the offspring's neurodevelopment, regardless of prematurity condition. This study aimed to assess TPL's impact on children's psychomotor and socioemotional development at 2 years of age. A cohort of mother-infants was recruited at the time of TPL diagnoses and followed up until 30 months of children's corrected age. Participants were classified into three groups regarding gestational age at delivery: Full-term TPL (n = 35), Late Preterm TPL (n = 67), and Very Preterm TPL (n = 41). A Control group (n = 62) of mothers without TPL and their infants born at term completed the sample. Children's assessment was performed using the Ages & Stages Questionnaires for psychomotor development, the Early Childhood Behavior Questionnaire-Very Short Form for temperament, and the Behaviour Rating Inventory of Executive Function-Preschool Version for executive functions. Then, MANCOVAs were conducted to detect differences between groups. TPL children, regardless of delivery time, showed worse emotional regulation (ps