Photothermal Nano-Immunotherapy Against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilm Infections
Methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections are a prevalent type of biofilm-associated infection with a poor prognosis and antibiotic resistance. The senescence of immune cells in the immune microenvironment contributes to biofilm formation. In this study, Ti₃C₂ MXene-PVA n...
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Veröffentlicht in: | Advanced healthcare materials 2024-11, p.e2403318 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections are a prevalent type of biofilm-associated infection with a poor prognosis and antibiotic resistance. The senescence of immune cells in the immune microenvironment contributes to biofilm formation. In this study, Ti₃C₂ MXene-PVA nanosheets loaded with metformin (Met@TiC) are developed for the treatment of MRSA biofilm infections. Nanosheets utilize near-infrared light to induce photothermal effects and provide direct bactericidal activity against biofilm structures. Met, which is known for its anti-inflammatory and anti-senescence properties, modulates immune responses by revitalizing the function of senescent macrophages within the biofilm microenvironment, thereby enhancing their phagocytic and biofilm-eradicating capabilities. The efficacy of this nanoplatform both in vitro and in an MRSA biofilm infection mouse model, demonstrating its potential as a photothermal nanoimmunotherapy for combating MRSA biofilm infections is validated. In summary, the Met@TiC nanoplatform offers a significant alternative to clinical solutions for MRSA biofilm infections. |
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ISSN: | 2192-2640 2192-2659 2192-2659 |
DOI: | 10.1002/adhm.202403318 |