Identifying left atrium and left atrial appendage prone to thrombus formation in patients with atrial fibrillation using statistical shape modeling

The morphology of the left atrium (LA) and left atrial appendage (LAA) is associated with LAA thrombus formation (LAAT) in patients with atrial fibrillation (AF). Statistical shape modeling (SSM) could be a comprehensive and objective method for evaluating LA/LAA shape, thereby improving LAAT risk a...

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Veröffentlicht in:	International journal of cardiology 2025-02, Vol.420, p.132731, Article 132731
Hauptverfasser:	Xu, Buyun, Wang, Yan, Zhao, Chengchen, Yu, Zhangjie, Luo, Kun, Xie, Yao, Xiang, Meixiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Atrial Appendage - diagnostic imaging Atrial Appendage - physiopathology Atrial fibrillation Atrial Fibrillation - diagnostic imaging Atrial Fibrillation - physiopathology Case-Control Studies Computed Tomography Angiography - methods Female Heart Atria - diagnostic imaging Heart Atria - physiopathology Humans Left atrial appendage Male Middle Aged Models, Statistical Retrospective Studies Risk Assessment - methods Statistical shape modeling Thrombosis Thrombosis - diagnostic imaging Thrombosis - etiology
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Zusammenfassung:	The morphology of the left atrium (LA) and left atrial appendage (LAA) is associated with LAA thrombus formation (LAAT) in patients with atrial fibrillation (AF). Statistical shape modeling (SSM) could be a comprehensive and objective method for evaluating LA/LAA shape, thereby improving LAAT risk assessment. In this individual-matched case-control study, 110 pairs of AF patients with or without LAAT were compared. Using SSM of cardiac computed tomography angiography images, we developed a LA/LAA shape deformation score (LADS). LADS was significantly higher in the LAAT group (4.0 ± 5.0 vs. -4.0 ± 6.5, P
ISSN:	0167-5273 1874-1754 1874-1754
DOI:	10.1016/j.ijcard.2024.132731