Fabrication of Engineered Drug–Polymer Composite Particles via Piezoelectric Inkjet Technique for Floating Drug Delivery Systems

This study presents a simple approach for fabricating low-density drug–polymer amorphous solid dispersions (ASDs) using a piezoelectric inkjet method, demonstrating potential applications for floating drug delivery systems (FDDS). By adjusting the ratio of two polymers, polylactic acid, and Eudragit RLPO, the floatability and drug release rate of the drug–polymer ASD particles can be easily manipulated. Kinetic model analyses have been conducted to interpret the drug release mechanism. This work offers a robust platform for exploring diverse polymer–drug combinations that are applicable to FDDS.