Clinical presentations and decreasing incidence of melanoma in pediatric and adolescent and young adult patients: 76,108 cases from a nationally representative cohort
Knowledge of melanoma presentations among pediatric and adolescent and young adult (AYA) patients are limited because of studies with small sample sizes. The objective of this study was to determine the incidence trends and melanoma presentations based on age, sex, race, and ethnicity using a large...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2024-11 |
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| creator | Ituarte, Bianca E. Taylor, Mitchell A. Thomas, Sierra I. Sharma, Divya Samson, Kaeli Oudenhoven, Mollie Harter, Nicole Wei, Erin X. Wysong, Ashley |
| description | Knowledge of melanoma presentations among pediatric and adolescent and young adult (AYA) patients are limited because of studies with small sample sizes.
The objective of this study was to determine the incidence trends and melanoma presentations based on age, sex, race, and ethnicity using a large cohort of diagnoses from 1997 to 2020.
A retrospective cohort study was completed using the National Childhood Cancer Registry from 1997 to 2020.
Incidence rates were 1.74 (95% CI: 1.64-1.84) and 62.05 (95% CI: 61.6-62.5) per 1-million-person years for pediatric and AYA patients, respectively. Women encompassed 62.3% of the cohort. Non-Hispanic White patients represented 87.5% of all diagnoses, with significantly higher incidence rates of melanoma compared with all other racial and ethnic groups in both age groups, respectively (P |
| doi_str_mv | 10.1016/j.jaad.2024.10.084 |
| format | Article |
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The objective of this study was to determine the incidence trends and melanoma presentations based on age, sex, race, and ethnicity using a large cohort of diagnoses from 1997 to 2020.
A retrospective cohort study was completed using the National Childhood Cancer Registry from 1997 to 2020.
Incidence rates were 1.74 (95% CI: 1.64-1.84) and 62.05 (95% CI: 61.6-62.5) per 1-million-person years for pediatric and AYA patients, respectively. Women encompassed 62.3% of the cohort. Non-Hispanic White patients represented 87.5% of all diagnoses, with significantly higher incidence rates of melanoma compared with all other racial and ethnic groups in both age groups, respectively (P < .001; P < .001). Superficial spreading was the most common of the specified histologic subtypes. The most common location in pediatric patients was the lower extremity, compared with trunk in AYA. There were statistically significant differences in the distributions of primary tumor location by sex, as well as by race and ethnicity, in both pediatric and AYA groups.
Limitations in this study include retrospective data, selection, and miscoding from individual registries.
There are significant differences in tumor characteristics among pediatric and AYA patients with cutaneous melanoma. Trends in incidence rates are decreasing for young patients diagnosed with cutaneous melanoma.</description><identifier>ISSN: 0190-9622</identifier><identifier>ISSN: 1097-6787</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2024.10.084</identifier><identifier>PMID: 39551155</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>cutaneous oncology ; NCCR database ; pediatric dermatology ; pediatric melanoma ; pediatric melanoma incidence ; SEER database</subject><ispartof>Journal of the American Academy of Dermatology, 2024-11</ispartof><rights>2024 American Academy of Dermatology, Inc.</rights><rights>Copyright © 2024 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-5131-1149</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39551155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ituarte, Bianca E.</creatorcontrib><creatorcontrib>Taylor, Mitchell A.</creatorcontrib><creatorcontrib>Thomas, Sierra I.</creatorcontrib><creatorcontrib>Sharma, Divya</creatorcontrib><creatorcontrib>Samson, Kaeli</creatorcontrib><creatorcontrib>Oudenhoven, Mollie</creatorcontrib><creatorcontrib>Harter, Nicole</creatorcontrib><creatorcontrib>Wei, Erin X.</creatorcontrib><creatorcontrib>Wysong, Ashley</creatorcontrib><title>Clinical presentations and decreasing incidence of melanoma in pediatric and adolescent and young adult patients: 76,108 cases from a nationally representative cohort</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Knowledge of melanoma presentations among pediatric and adolescent and young adult (AYA) patients are limited because of studies with small sample sizes.
The objective of this study was to determine the incidence trends and melanoma presentations based on age, sex, race, and ethnicity using a large cohort of diagnoses from 1997 to 2020.
A retrospective cohort study was completed using the National Childhood Cancer Registry from 1997 to 2020.
Incidence rates were 1.74 (95% CI: 1.64-1.84) and 62.05 (95% CI: 61.6-62.5) per 1-million-person years for pediatric and AYA patients, respectively. Women encompassed 62.3% of the cohort. Non-Hispanic White patients represented 87.5% of all diagnoses, with significantly higher incidence rates of melanoma compared with all other racial and ethnic groups in both age groups, respectively (P < .001; P < .001). Superficial spreading was the most common of the specified histologic subtypes. The most common location in pediatric patients was the lower extremity, compared with trunk in AYA. There were statistically significant differences in the distributions of primary tumor location by sex, as well as by race and ethnicity, in both pediatric and AYA groups.
Limitations in this study include retrospective data, selection, and miscoding from individual registries.
There are significant differences in tumor characteristics among pediatric and AYA patients with cutaneous melanoma. Trends in incidence rates are decreasing for young patients diagnosed with cutaneous melanoma.</description><subject>cutaneous oncology</subject><subject>NCCR database</subject><subject>pediatric dermatology</subject><subject>pediatric melanoma</subject><subject>pediatric melanoma incidence</subject><subject>SEER database</subject><issn>0190-9622</issn><issn>1097-6787</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpFUcuO1DAQtBCIHRZ-gAPykQMZ2nk4MeKCRrAgrcQFzlaP3QGPHDvYyUrzQ3wnzuyiPbW6XF3u6mLstYC9ACHfn_YnRLuvoW4LsIehfcJ2AlRfyX7on7IdCAWVknV9xV7kfAIA1Tb9c3bVqK4Tout27O_Bu-AMej4nyhQWXFwMmWOw3JJJhNmFX9wF4ywFQzyOfCKPIU5YUD6TdbgkZy4TaKOnbIrMpT3HtcyiXf3C5yJc8PyB9_KdgIEbzJT5mOLEkYfLt-j9mSd63OSOuIm_Y1pesmcj-kyvHuo1-_nl84_D1-r2-823w6fbiorvrqIBwBjVmRFIGhzV8Qg4Ctke5WCt6lrbj9AN0EvRq2YUSow1DFaCKoTy3Fyzt_e6c4p_VsqLnlzx44thimvWjaiVHGoJUKhvHqjrcSKr5-QmTGf9_7aF8PGeQGXhO0dJZ-O2G1qXyCzaRqcF6C1KfdJblHqLcsNKlM0_HFeTWw</recordid><startdate>20241117</startdate><enddate>20241117</enddate><creator>Ituarte, Bianca E.</creator><creator>Taylor, Mitchell A.</creator><creator>Thomas, Sierra I.</creator><creator>Sharma, Divya</creator><creator>Samson, Kaeli</creator><creator>Oudenhoven, Mollie</creator><creator>Harter, Nicole</creator><creator>Wei, Erin X.</creator><creator>Wysong, Ashley</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5131-1149</orcidid></search><sort><creationdate>20241117</creationdate><title>Clinical presentations and decreasing incidence of melanoma in pediatric and adolescent and young adult patients: 76,108 cases from a nationally representative cohort</title><author>Ituarte, Bianca E. ; Taylor, Mitchell A. ; Thomas, Sierra I. ; Sharma, Divya ; Samson, Kaeli ; Oudenhoven, Mollie ; Harter, Nicole ; Wei, Erin X. ; Wysong, Ashley</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1095-e800cc95cf0e6caf9bb0af164b68dd954d7f0580761793f191f208d609b689543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>cutaneous oncology</topic><topic>NCCR database</topic><topic>pediatric dermatology</topic><topic>pediatric melanoma</topic><topic>pediatric melanoma incidence</topic><topic>SEER database</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ituarte, Bianca E.</creatorcontrib><creatorcontrib>Taylor, Mitchell A.</creatorcontrib><creatorcontrib>Thomas, Sierra I.</creatorcontrib><creatorcontrib>Sharma, Divya</creatorcontrib><creatorcontrib>Samson, Kaeli</creatorcontrib><creatorcontrib>Oudenhoven, Mollie</creatorcontrib><creatorcontrib>Harter, Nicole</creatorcontrib><creatorcontrib>Wei, Erin X.</creatorcontrib><creatorcontrib>Wysong, Ashley</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ituarte, Bianca E.</au><au>Taylor, Mitchell A.</au><au>Thomas, Sierra I.</au><au>Sharma, Divya</au><au>Samson, Kaeli</au><au>Oudenhoven, Mollie</au><au>Harter, Nicole</au><au>Wei, Erin X.</au><au>Wysong, Ashley</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical presentations and decreasing incidence of melanoma in pediatric and adolescent and young adult patients: 76,108 cases from a nationally representative cohort</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2024-11-17</date><risdate>2024</risdate><issn>0190-9622</issn><issn>1097-6787</issn><eissn>1097-6787</eissn><abstract>Knowledge of melanoma presentations among pediatric and adolescent and young adult (AYA) patients are limited because of studies with small sample sizes.
The objective of this study was to determine the incidence trends and melanoma presentations based on age, sex, race, and ethnicity using a large cohort of diagnoses from 1997 to 2020.
A retrospective cohort study was completed using the National Childhood Cancer Registry from 1997 to 2020.
Incidence rates were 1.74 (95% CI: 1.64-1.84) and 62.05 (95% CI: 61.6-62.5) per 1-million-person years for pediatric and AYA patients, respectively. Women encompassed 62.3% of the cohort. Non-Hispanic White patients represented 87.5% of all diagnoses, with significantly higher incidence rates of melanoma compared with all other racial and ethnic groups in both age groups, respectively (P < .001; P < .001). Superficial spreading was the most common of the specified histologic subtypes. The most common location in pediatric patients was the lower extremity, compared with trunk in AYA. There were statistically significant differences in the distributions of primary tumor location by sex, as well as by race and ethnicity, in both pediatric and AYA groups.
Limitations in this study include retrospective data, selection, and miscoding from individual registries.
There are significant differences in tumor characteristics among pediatric and AYA patients with cutaneous melanoma. Trends in incidence rates are decreasing for young patients diagnosed with cutaneous melanoma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39551155</pmid><doi>10.1016/j.jaad.2024.10.084</doi><orcidid>https://orcid.org/0000-0001-5131-1149</orcidid></addata></record> |
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| issn | 0190-9622 1097-6787 1097-6787 |
| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | cutaneous oncology NCCR database pediatric dermatology pediatric melanoma pediatric melanoma incidence SEER database |
| title | Clinical presentations and decreasing incidence of melanoma in pediatric and adolescent and young adult patients: 76,108 cases from a nationally representative cohort |
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