Clinical presentations and decreasing incidence of melanoma in pediatric and adolescent and young adult patients: 76,108 cases from a nationally representative cohort

Knowledge of melanoma presentations among pediatric and adolescent and young adult (AYA) patients are limited because of studies with small sample sizes. The objective of this study was to determine the incidence trends and melanoma presentations based on age, sex, race, and ethnicity using a large cohort of diagnoses from 1997 to 2020. A retrospective cohort study was completed using the National Childhood Cancer Registry from 1997 to 2020. Incidence rates were 1.74 (95% CI: 1.64-1.84) and 62.05 (95% CI: 61.6-62.5) per 1-million-person years for pediatric and AYA patients, respectively. Women encompassed 62.3% of the cohort. Non-Hispanic White patients represented 87.5% of all diagnoses, with significantly higher incidence rates of melanoma compared with all other racial and ethnic groups in both age groups, respectively (P