Anticoagulation Usage and Thrombolytic Therapy in Subjects with Atrial Fibrillation Associated Ischaemic Stroke

Atrial Fibrillation (AF) causes up to 20% of ischaemic strokes and 30% in some populations such as those over 80 years. Previous research in our population showed that widespread adoption of Direct Oral Anticoagulant (DOAC) prophylaxis had not been associated with a reduction in AF associated stroke prevalence but there was a considerable rate of breakthrough stroke in patients receiving anticoagulation and anticoagulation rate may be affected by increasing use of DOACs. We undertook a more detailed study using the Irish National Audit of Stroke (INAS) to determine the characteristics of anticoagulation practice in AF associated stroke, particularly breakthrough stroke, adherence to prescribing guidelines and effect on thrombolysis rate. Data from INASwere analysed for the period 2017-2022 inclusive as part of a cross-sectional, cohort study. Data on pre stroke, and discharge disability (modified Rankin Score (mRS)) were collected in addition to age, sex, length of stay and thrombolysis rate. An enhanced dataset with additional questions about adherence with prescription, reasons for non-concordance and International Normalized Ratio (INR) control for receiving Warfarin was collected for 2022 was also considered separately. Comparisons for continuous / quantitative data were made using Student's t tests and for proportional data using Pearson's Chi Square statistics and logistic regression analysesResults. Complete AF Data were available on 22485 of 26829 strokes admitted over this period. Of these strokes with AF data, 19260 (85.6%) were ischaemic, mean age was 71.8 and 57.1% male. AF was found in 5321 of these ischaemic strokes and this AF was identified pre-stroke in 2835 in 2835 (53.3%). 80.4% of patients with known AF had been prescribed anticoagulation. The population with previously unknown AF were significantly younger on average than those on anticoagulation (76.8 years vs. 79.1 years (p