Anti N-methyl-D-aspartate receptor encephalitis during pregnancy: A case report
•The NMDAR encephalitis is an immune-mediated disease characterized by a neuropsychiatric syndrome.•Its predominantly psychiatric symptomatology can lead to diagnostic challenges.•In 50 % of cases, immunoglobulin are combined with corticosteroids.•The balance benefits/risks of oophorectomy during pr...
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| Veröffentlicht in: | Journal of gynecology obstetrics and human reproduction 2025-02, Vol.54 (2), p.102876, Article 102876 |
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| container_issue | 2 |
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| container_title | Journal of gynecology obstetrics and human reproduction |
| container_volume | 54 |
| creator | Kennel, Leïa Luton, Dominique Gressier, Florence Daffos, Chloé Corruble, Emmanuelle Julé, Laure Brunet de Courssou, Jean-Baptiste Szmulewicz, Claire |
| description | •The NMDAR encephalitis is an immune-mediated disease characterized by a neuropsychiatric syndrome.•Its predominantly psychiatric symptomatology can lead to diagnostic challenges.•In 50 % of cases, immunoglobulin are combined with corticosteroids.•The balance benefits/risks of oophorectomy during pregnancy has to be considered.
Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is an immune-mediated encephalitis that primarily affects young women. Due to the psychiatric and neurological symptoms, the diagnosis can be challenging, especially during pregnancy. During pregnancy, treatments must take into account the fetal and neonatal risk and the risk of premature delivery. We report a case of anti-NMDA encephalitis in a 31-years-old, 30 weeks pregnant women characterized by predominantly psychiatric symptoms, associated with ovarian teratoma. First-line treatments have led to an improvement in symptoms, allowing the pregnancy to be carried to term and a vaginal delivery. |
| doi_str_mv | 10.1016/j.jogoh.2024.102876 |
| format | Article |
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Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is an immune-mediated encephalitis that primarily affects young women. Due to the psychiatric and neurological symptoms, the diagnosis can be challenging, especially during pregnancy. During pregnancy, treatments must take into account the fetal and neonatal risk and the risk of premature delivery. We report a case of anti-NMDA encephalitis in a 31-years-old, 30 weeks pregnant women characterized by predominantly psychiatric symptoms, associated with ovarian teratoma. First-line treatments have led to an improvement in symptoms, allowing the pregnancy to be carried to term and a vaginal delivery.</description><identifier>ISSN: 2468-7847</identifier><identifier>EISSN: 2468-7847</identifier><identifier>DOI: 10.1016/j.jogoh.2024.102876</identifier><identifier>PMID: 39542173</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Adult ; Anti-N-methyl-D-aspartate receptor ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnosis ; Encephalitis ; Female ; Humans ; Immune-médiated encephalitis ; Ovarian Neoplasms - complications ; Pregnancy ; Pregnancy Complications ; Teratoma ; Teratoma - complications</subject><ispartof>Journal of gynecology obstetrics and human reproduction, 2025-02, Vol.54 (2), p.102876, Article 102876</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Masson SAS.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c239t-572fdcf390156fab18282aa5d544427d79e14a1922e9e6eb37bb75a79bd7840c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39542173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kennel, Leïa</creatorcontrib><creatorcontrib>Luton, Dominique</creatorcontrib><creatorcontrib>Gressier, Florence</creatorcontrib><creatorcontrib>Daffos, Chloé</creatorcontrib><creatorcontrib>Corruble, Emmanuelle</creatorcontrib><creatorcontrib>Julé, Laure</creatorcontrib><creatorcontrib>Brunet de Courssou, Jean-Baptiste</creatorcontrib><creatorcontrib>Szmulewicz, Claire</creatorcontrib><title>Anti N-methyl-D-aspartate receptor encephalitis during pregnancy: A case report</title><title>Journal of gynecology obstetrics and human reproduction</title><addtitle>J Gynecol Obstet Hum Reprod</addtitle><description>•The NMDAR encephalitis is an immune-mediated disease characterized by a neuropsychiatric syndrome.•Its predominantly psychiatric symptomatology can lead to diagnostic challenges.•In 50 % of cases, immunoglobulin are combined with corticosteroids.•The balance benefits/risks of oophorectomy during pregnancy has to be considered.
Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is an immune-mediated encephalitis that primarily affects young women. Due to the psychiatric and neurological symptoms, the diagnosis can be challenging, especially during pregnancy. During pregnancy, treatments must take into account the fetal and neonatal risk and the risk of premature delivery. We report a case of anti-NMDA encephalitis in a 31-years-old, 30 weeks pregnant women characterized by predominantly psychiatric symptoms, associated with ovarian teratoma. First-line treatments have led to an improvement in symptoms, allowing the pregnancy to be carried to term and a vaginal delivery.</description><subject>Adult</subject><subject>Anti-N-methyl-D-aspartate receptor</subject><subject>Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnosis</subject><subject>Encephalitis</subject><subject>Female</subject><subject>Humans</subject><subject>Immune-médiated encephalitis</subject><subject>Ovarian Neoplasms - complications</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Teratoma</subject><subject>Teratoma - complications</subject><issn>2468-7847</issn><issn>2468-7847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQgIMottT-AkH26GVrXrvZFTyU-oRiL3oO2exsm2VfJqnQf29qq3jyNMPwzetD6JLgGcEkvalndb_uNzOKKQ8Vmon0BI0pT7NYZFyc_slHaOpcjTEmGU1Tlp6jEcsTTolgY7Sad95Er3ELfrNr4vtYuUFZrzxEFjQMvrcRdCHZqMZ446Jya023jgYL6051encbzSOt3B4feusv0FmlGgfTY5yg98eHt8VzvFw9vSzmy1hTlvs4EbQqdcVyTJK0UkU4LaNKJWXCOaeiFDkQrkhOKeSQQsFEUYhEibwow0tYswm6PswdbP-xBedla5yGplEd9FsnGaFZRjllNKDsgGrbO2ehkoM1rbI7SbDcy5S1_JYp9zLlQWboujou2BYtlL89P-oCcHcAILz5acBKp81eVWmCOS_L3vy74AueSoW2</recordid><startdate>20250201</startdate><enddate>20250201</enddate><creator>Kennel, Leïa</creator><creator>Luton, Dominique</creator><creator>Gressier, Florence</creator><creator>Daffos, Chloé</creator><creator>Corruble, Emmanuelle</creator><creator>Julé, Laure</creator><creator>Brunet de Courssou, Jean-Baptiste</creator><creator>Szmulewicz, Claire</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20250201</creationdate><title>Anti N-methyl-D-aspartate receptor encephalitis during pregnancy: A case report</title><author>Kennel, Leïa ; Luton, Dominique ; Gressier, Florence ; Daffos, Chloé ; Corruble, Emmanuelle ; Julé, Laure ; Brunet de Courssou, Jean-Baptiste ; Szmulewicz, Claire</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c239t-572fdcf390156fab18282aa5d544427d79e14a1922e9e6eb37bb75a79bd7840c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Anti-N-methyl-D-aspartate receptor</topic><topic>Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnosis</topic><topic>Encephalitis</topic><topic>Female</topic><topic>Humans</topic><topic>Immune-médiated encephalitis</topic><topic>Ovarian Neoplasms - complications</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Teratoma</topic><topic>Teratoma - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kennel, Leïa</creatorcontrib><creatorcontrib>Luton, Dominique</creatorcontrib><creatorcontrib>Gressier, Florence</creatorcontrib><creatorcontrib>Daffos, Chloé</creatorcontrib><creatorcontrib>Corruble, Emmanuelle</creatorcontrib><creatorcontrib>Julé, Laure</creatorcontrib><creatorcontrib>Brunet de Courssou, Jean-Baptiste</creatorcontrib><creatorcontrib>Szmulewicz, Claire</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gynecology obstetrics and human reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kennel, Leïa</au><au>Luton, Dominique</au><au>Gressier, Florence</au><au>Daffos, Chloé</au><au>Corruble, Emmanuelle</au><au>Julé, Laure</au><au>Brunet de Courssou, Jean-Baptiste</au><au>Szmulewicz, Claire</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti N-methyl-D-aspartate receptor encephalitis during pregnancy: A case report</atitle><jtitle>Journal of gynecology obstetrics and human reproduction</jtitle><addtitle>J Gynecol Obstet Hum Reprod</addtitle><date>2025-02-01</date><risdate>2025</risdate><volume>54</volume><issue>2</issue><spage>102876</spage><pages>102876-</pages><artnum>102876</artnum><issn>2468-7847</issn><eissn>2468-7847</eissn><abstract>•The NMDAR encephalitis is an immune-mediated disease characterized by a neuropsychiatric syndrome.•Its predominantly psychiatric symptomatology can lead to diagnostic challenges.•In 50 % of cases, immunoglobulin are combined with corticosteroids.•The balance benefits/risks of oophorectomy during pregnancy has to be considered.
Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is an immune-mediated encephalitis that primarily affects young women. Due to the psychiatric and neurological symptoms, the diagnosis can be challenging, especially during pregnancy. During pregnancy, treatments must take into account the fetal and neonatal risk and the risk of premature delivery. We report a case of anti-NMDA encephalitis in a 31-years-old, 30 weeks pregnant women characterized by predominantly psychiatric symptoms, associated with ovarian teratoma. First-line treatments have led to an improvement in symptoms, allowing the pregnancy to be carried to term and a vaginal delivery.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>39542173</pmid><doi>10.1016/j.jogoh.2024.102876</doi></addata></record> |
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| ispartof | Journal of gynecology obstetrics and human reproduction, 2025-02, Vol.54 (2), p.102876, Article 102876 |
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| subjects | Adult Anti-N-methyl-D-aspartate receptor Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnosis Encephalitis Female Humans Immune-médiated encephalitis Ovarian Neoplasms - complications Pregnancy Pregnancy Complications Teratoma Teratoma - complications |
| title | Anti N-methyl-D-aspartate receptor encephalitis during pregnancy: A case report |
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