Recent Developments in Glioblastoma‐On‐A‐Chip for Advanced Drug Screening Applications

Glioblastoma (GBM) is an aggressive form of cancer, comprising ≈80% of malignant brain tumors. However, there are no effective treatments for GBM due to its heterogeneity and the presence of the blood‐brain barrier (BBB), which restricts the delivery of therapeutics to the brain. Despite in vitro models contributing to the understanding of GBM, conventional 2D models oversimplify the complex tumor microenvironment. Organ‐on‐a‐chip (OoC) models have emerged as promising platforms that recapitulate human tissue physiology, enabling disease modeling, drug screening, and personalized medicine. There is a sudden increase in GBM‐on‐a‐chip models that can significantly advance the knowledge of GBM etiology and revolutionize drug development by reducing animal testing and enhancing translation to the clinic. In this review, an overview of GBM‐on‐a‐chip models and their applications is reported for drug screening and discussed current challenges and potential future directions for GBM‐on‐a‐chip models. Glioblastoma, an aggressive brain cancer, possesses treatment challenges due to its complexity and the blood‐brain barrier. Organ‐on‐a‐chip models are emerging as valuable tools for investigating GBM and testing novel treatments by recapitulating native tissue microenvironments. These models have the potential to enrich the understanding of GBM and advance drug development processes.