An antimicrobial blue light prototype device controls infected wounds in a preclinical porcine model

We developed a translational prototype antimicrobial blue light (ABL) device for treating skin wounds with ABL. Partial-thickness surgical wounds were created in live swine, an animal whose skin is considered the most like human skin, then heavily contaminated and left untreated for 24 hours with me...

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Veröffentlicht in:The Journal of infectious diseases 2024-11
Hauptverfasser: Negri, Laisa Bonafim, Farinelli, William, Korupolu, Sandeep, Wang, Ying, Mannaa, Yara, Lee, Hang, Hui, Jie, Dong, Pu-Ting, Slate, Andrea, Tam, Joshua, Anderson, R Rox, Yun, Seok-Hyun Andy, Gelfand, Jeffrey A
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container_title The Journal of infectious diseases
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creator Negri, Laisa Bonafim
Farinelli, William
Korupolu, Sandeep
Wang, Ying
Mannaa, Yara
Lee, Hang
Hui, Jie
Dong, Pu-Ting
Slate, Andrea
Tam, Joshua
Anderson, R Rox
Yun, Seok-Hyun Andy
Gelfand, Jeffrey A
description We developed a translational prototype antimicrobial blue light (ABL) device for treating skin wounds with ABL. Partial-thickness surgical wounds were created in live swine, an animal whose skin is considered the most like human skin, then heavily contaminated and left untreated for 24 hours with methicillin-resistant Staphylococcus aureus (MRSA). ABL treatment stabilized and reduced MRSA infection by greater than four orders of magnitude (>99.99%; p
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Partial-thickness surgical wounds were created in live swine, an animal whose skin is considered the most like human skin, then heavily contaminated and left untreated for 24 hours with methicillin-resistant Staphylococcus aureus (MRSA). ABL treatment stabilized and reduced MRSA infection by greater than four orders of magnitude (&gt;99.99%; p&lt;0.0001) compared with untreated wounds in the same animal, after only two daily treatments. These data support further development of such devices for controlling infection in skin wounds. ABL, with or without concomitant administration of negative pressure, antimicrobials, or photosensitizers, could play an important role in modern wound care by reducing the amount, duration, and cost of antibiotics needed, helping reduce AMR. No such device for treating human cutaneous wounds currently exists. 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source Oxford University Press Journals All Titles (1996-Current)
title An antimicrobial blue light prototype device controls infected wounds in a preclinical porcine model
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