Pregnancy in Dystonia or Tourette's Patients with DBS. Fourteen News Cases and a Review of the Literature

Background Deep Brain Stimulation (DBS) has been demonstrated to improve quality of life in patients with refractory dystonia and Tourette's syndrome (TS). Because of the young age at onset of these disorders, and the marked benefit from DBS, pregnancy in patients who have received DBS is becoming a more frequent clinical occurrence, although clear management guidelines are lacking. Cases We report 14 new pregnancies in patients with dystonia or TS and DBS. Literature Review Upon review of the literature, 23 pregnancies in patients with dystonia or TS were previously reported in seven articles. Conclusion Based on the available data from a total of 37 pregnancies, DBS does not seem associated with worse pregnancy outcome. However, careful planning and communication between neurologist, anesthesiologist and obstetrician are key. A registry on pregnancy outcome in patients with DBS should be generated to facilitate the development of guidelines.