Study of penehyclidine for the prevention of postoperative nausea and vomiting following laparoscopic sleeve gastrectomy under general anesthesia: a randomized, prospective, double-blind trial
Purpose To investigate the efficacy of penehyclidine (PHC) for preventing postoperative nausea and vomiting (PONV) after laparoscopic sleeve gastrectomy (LSG) under general anesthesia. Materials and methods In this prospective study, 219 patients who were scheduled to undergo LSG were randomly assig...
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| Veröffentlicht in: | Journal of anesthesia 2025-02, Vol.39 (1), p.67-74 |
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| creator | Wang, Min Wang, Ting-Ting Liu, Chen Wu, Zhou-Quan |
| description | Purpose
To investigate the efficacy of penehyclidine (PHC) for preventing postoperative nausea and vomiting (PONV) after laparoscopic sleeve gastrectomy (LSG) under general anesthesia.
Materials and methods
In this prospective study, 219 patients who were scheduled to undergo LSG were randomly assigned to three cohorts: the control cohort (received normal saline), the infusion cohort (administered 0.25 mg of PHC intravenously followed by an additional 0.25 mg through an intravenous analgesia pump for 48 h after LSG), and the bolus cohort (received a single intravenous dose of 0.5 mg of PHC). The study outcomes included the incidence of PONV within the first 48 h postoperatively, the severity and intensity of PONV, side effects and postoperative recovery outcomes. Univariate and multivariate logistic analyses were performed to identify independent risk factors associated with PONV.
Results
Compared with the control cohort, both the infusion and bolus cohorts presented considerably lower incidences of PONV (61.64% vs. 12.33% vs. 38.36%,
P
|
| doi_str_mv | 10.1007/s00540-024-03424-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3128758005</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3128758005</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-e2d5c02e9e34140a9ee7e665a0c61948663e6d778fb8b1f993c204bd295d8a9d3</originalsourceid><addsrcrecordid>eNp9kUuPFCEUhStG47Sjf8CFYeliSnnUA9yZia9kEhfqmlBwq4cJBSVQPWl_nT_NO9OjSzdAwrnfOXCa5iWjbxil49tCad_RlvKupaLDVTxqdqwTspWiV4-bHVVMtHIY5FnzrJQbSunAmHjanAnVcyk52zW_v9XNHUmayQoRro82eOcjkDllUq-BrBkOEKtP8V6TSk0rZFP9AUg0WwFDTHTkkBZffdzjXAjp9u4UzGpyKjat3pISADlkb0rNYGtajmSLDjLZo2s2ASFQ0K94844YkpGJxF_gLjBBKivOoOMFcWmbArRT8GhaszfhefNkNqHAi4f9vPnx8cP3y8_t1ddPXy7fX7WWc1lb4K63lIMC0bGOGgUwwjD0htqBqQ4_ScDgxlHOk5zYrJSwnHaT46p30ignzpvXJy7m-blhWL34YiEETJ62ogXjcuwlVoJSfpJajF4yzHrNfjH5qBnVd83pU3Mam9P3zWmBQ68e-Nu0gPs38rcqFIiToOBV3EPWN2nLEd_8P-wfRa-p8A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3128758005</pqid></control><display><type>article</type><title>Study of penehyclidine for the prevention of postoperative nausea and vomiting following laparoscopic sleeve gastrectomy under general anesthesia: a randomized, prospective, double-blind trial</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Wang, Min ; Wang, Ting-Ting ; Liu, Chen ; Wu, Zhou-Quan</creator><creatorcontrib>Wang, Min ; Wang, Ting-Ting ; Liu, Chen ; Wu, Zhou-Quan</creatorcontrib><description>Purpose
To investigate the efficacy of penehyclidine (PHC) for preventing postoperative nausea and vomiting (PONV) after laparoscopic sleeve gastrectomy (LSG) under general anesthesia.
Materials and methods
In this prospective study, 219 patients who were scheduled to undergo LSG were randomly assigned to three cohorts: the control cohort (received normal saline), the infusion cohort (administered 0.25 mg of PHC intravenously followed by an additional 0.25 mg through an intravenous analgesia pump for 48 h after LSG), and the bolus cohort (received a single intravenous dose of 0.5 mg of PHC). The study outcomes included the incidence of PONV within the first 48 h postoperatively, the severity and intensity of PONV, side effects and postoperative recovery outcomes. Univariate and multivariate logistic analyses were performed to identify independent risk factors associated with PONV.
Results
Compared with the control cohort, both the infusion and bolus cohorts presented considerably lower incidences of PONV (61.64% vs. 12.33% vs. 38.36%,
P
< 0.05), as well as significantly decreased PONV severities (
P
< 0.05) and intensities (
P
< 0.05). There were no significant differences in side effects and postoperative recovery outcomes among the three cohorts, with the exception of dry mouthand the administration of rescue antiemetic therapy (
P
< 0.05). Additionally, the Apfel risk score and PHC intervention were identified as independent risk factors associated with PONV incidence following LSG (
P
< 0.05).
Results
PHC effectively prevented PONV occurrence and reduced its severity in LSG patients without decreasing postoperative recovery outcomes, particularly in the infusion cohort.</description><identifier>ISSN: 0913-8668</identifier><identifier>ISSN: 1438-8359</identifier><identifier>EISSN: 1438-8359</identifier><identifier>DOI: 10.1007/s00540-024-03424-3</identifier><identifier>PMID: 39528821</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Adult ; Anesthesia, General - methods ; Anesthesiology ; Antiemetics - administration & dosage ; Antiemetics - therapeutic use ; Critical Care Medicine ; Double-Blind Method ; Emergency Medicine ; Female ; Gastrectomy - adverse effects ; Gastrectomy - methods ; Humans ; Intensive ; Laparoscopy - adverse effects ; Laparoscopy - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Pain Medicine ; Postoperative Nausea and Vomiting - prevention & control ; Prospective Studies ; Quinuclidines - administration & dosage ; Quinuclidines - therapeutic use ; Treatment Outcome</subject><ispartof>Journal of anesthesia, 2025-02, Vol.39 (1), p.67-74</ispartof><rights>The Author(s) under exclusive licence to Japanese Society of Anesthesiologists 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s) under exclusive licence to Japanese Society of Anesthesiologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-e2d5c02e9e34140a9ee7e665a0c61948663e6d778fb8b1f993c204bd295d8a9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00540-024-03424-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00540-024-03424-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39528821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Wang, Ting-Ting</creatorcontrib><creatorcontrib>Liu, Chen</creatorcontrib><creatorcontrib>Wu, Zhou-Quan</creatorcontrib><title>Study of penehyclidine for the prevention of postoperative nausea and vomiting following laparoscopic sleeve gastrectomy under general anesthesia: a randomized, prospective, double-blind trial</title><title>Journal of anesthesia</title><addtitle>J Anesth</addtitle><addtitle>J Anesth</addtitle><description>Purpose
To investigate the efficacy of penehyclidine (PHC) for preventing postoperative nausea and vomiting (PONV) after laparoscopic sleeve gastrectomy (LSG) under general anesthesia.
Materials and methods
In this prospective study, 219 patients who were scheduled to undergo LSG were randomly assigned to three cohorts: the control cohort (received normal saline), the infusion cohort (administered 0.25 mg of PHC intravenously followed by an additional 0.25 mg through an intravenous analgesia pump for 48 h after LSG), and the bolus cohort (received a single intravenous dose of 0.5 mg of PHC). The study outcomes included the incidence of PONV within the first 48 h postoperatively, the severity and intensity of PONV, side effects and postoperative recovery outcomes. Univariate and multivariate logistic analyses were performed to identify independent risk factors associated with PONV.
Results
Compared with the control cohort, both the infusion and bolus cohorts presented considerably lower incidences of PONV (61.64% vs. 12.33% vs. 38.36%,
P
< 0.05), as well as significantly decreased PONV severities (
P
< 0.05) and intensities (
P
< 0.05). There were no significant differences in side effects and postoperative recovery outcomes among the three cohorts, with the exception of dry mouthand the administration of rescue antiemetic therapy (
P
< 0.05). Additionally, the Apfel risk score and PHC intervention were identified as independent risk factors associated with PONV incidence following LSG (
P
< 0.05).
Results
PHC effectively prevented PONV occurrence and reduced its severity in LSG patients without decreasing postoperative recovery outcomes, particularly in the infusion cohort.</description><subject>Adult</subject><subject>Anesthesia, General - methods</subject><subject>Anesthesiology</subject><subject>Antiemetics - administration & dosage</subject><subject>Antiemetics - therapeutic use</subject><subject>Critical Care Medicine</subject><subject>Double-Blind Method</subject><subject>Emergency Medicine</subject><subject>Female</subject><subject>Gastrectomy - adverse effects</subject><subject>Gastrectomy - methods</subject><subject>Humans</subject><subject>Intensive</subject><subject>Laparoscopy - adverse effects</subject><subject>Laparoscopy - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Postoperative Nausea and Vomiting - prevention & control</subject><subject>Prospective Studies</subject><subject>Quinuclidines - administration & dosage</subject><subject>Quinuclidines - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0913-8668</issn><issn>1438-8359</issn><issn>1438-8359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuPFCEUhStG47Sjf8CFYeliSnnUA9yZia9kEhfqmlBwq4cJBSVQPWl_nT_NO9OjSzdAwrnfOXCa5iWjbxil49tCad_RlvKupaLDVTxqdqwTspWiV4-bHVVMtHIY5FnzrJQbSunAmHjanAnVcyk52zW_v9XNHUmayQoRro82eOcjkDllUq-BrBkOEKtP8V6TSk0rZFP9AUg0WwFDTHTkkBZffdzjXAjp9u4UzGpyKjat3pISADlkb0rNYGtajmSLDjLZo2s2ASFQ0K94844YkpGJxF_gLjBBKivOoOMFcWmbArRT8GhaszfhefNkNqHAi4f9vPnx8cP3y8_t1ddPXy7fX7WWc1lb4K63lIMC0bGOGgUwwjD0htqBqQ4_ScDgxlHOk5zYrJSwnHaT46p30ignzpvXJy7m-blhWL34YiEETJ62ogXjcuwlVoJSfpJajF4yzHrNfjH5qBnVd83pU3Mam9P3zWmBQ68e-Nu0gPs38rcqFIiToOBV3EPWN2nLEd_8P-wfRa-p8A</recordid><startdate>202502</startdate><enddate>202502</enddate><creator>Wang, Min</creator><creator>Wang, Ting-Ting</creator><creator>Liu, Chen</creator><creator>Wu, Zhou-Quan</creator><general>Springer Nature Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202502</creationdate><title>Study of penehyclidine for the prevention of postoperative nausea and vomiting following laparoscopic sleeve gastrectomy under general anesthesia: a randomized, prospective, double-blind trial</title><author>Wang, Min ; Wang, Ting-Ting ; Liu, Chen ; Wu, Zhou-Quan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-e2d5c02e9e34140a9ee7e665a0c61948663e6d778fb8b1f993c204bd295d8a9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Anesthesia, General - methods</topic><topic>Anesthesiology</topic><topic>Antiemetics - administration & dosage</topic><topic>Antiemetics - therapeutic use</topic><topic>Critical Care Medicine</topic><topic>Double-Blind Method</topic><topic>Emergency Medicine</topic><topic>Female</topic><topic>Gastrectomy - adverse effects</topic><topic>Gastrectomy - methods</topic><topic>Humans</topic><topic>Intensive</topic><topic>Laparoscopy - adverse effects</topic><topic>Laparoscopy - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Postoperative Nausea and Vomiting - prevention & control</topic><topic>Prospective Studies</topic><topic>Quinuclidines - administration & dosage</topic><topic>Quinuclidines - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Wang, Ting-Ting</creatorcontrib><creatorcontrib>Liu, Chen</creatorcontrib><creatorcontrib>Wu, Zhou-Quan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Min</au><au>Wang, Ting-Ting</au><au>Liu, Chen</au><au>Wu, Zhou-Quan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of penehyclidine for the prevention of postoperative nausea and vomiting following laparoscopic sleeve gastrectomy under general anesthesia: a randomized, prospective, double-blind trial</atitle><jtitle>Journal of anesthesia</jtitle><stitle>J Anesth</stitle><addtitle>J Anesth</addtitle><date>2025-02</date><risdate>2025</risdate><volume>39</volume><issue>1</issue><spage>67</spage><epage>74</epage><pages>67-74</pages><issn>0913-8668</issn><issn>1438-8359</issn><eissn>1438-8359</eissn><abstract>Purpose
To investigate the efficacy of penehyclidine (PHC) for preventing postoperative nausea and vomiting (PONV) after laparoscopic sleeve gastrectomy (LSG) under general anesthesia.
Materials and methods
In this prospective study, 219 patients who were scheduled to undergo LSG were randomly assigned to three cohorts: the control cohort (received normal saline), the infusion cohort (administered 0.25 mg of PHC intravenously followed by an additional 0.25 mg through an intravenous analgesia pump for 48 h after LSG), and the bolus cohort (received a single intravenous dose of 0.5 mg of PHC). The study outcomes included the incidence of PONV within the first 48 h postoperatively, the severity and intensity of PONV, side effects and postoperative recovery outcomes. Univariate and multivariate logistic analyses were performed to identify independent risk factors associated with PONV.
Results
Compared with the control cohort, both the infusion and bolus cohorts presented considerably lower incidences of PONV (61.64% vs. 12.33% vs. 38.36%,
P
< 0.05), as well as significantly decreased PONV severities (
P
< 0.05) and intensities (
P
< 0.05). There were no significant differences in side effects and postoperative recovery outcomes among the three cohorts, with the exception of dry mouthand the administration of rescue antiemetic therapy (
P
< 0.05). Additionally, the Apfel risk score and PHC intervention were identified as independent risk factors associated with PONV incidence following LSG (
P
< 0.05).
Results
PHC effectively prevented PONV occurrence and reduced its severity in LSG patients without decreasing postoperative recovery outcomes, particularly in the infusion cohort.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>39528821</pmid><doi>10.1007/s00540-024-03424-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Anesthesia, General - methods Anesthesiology Antiemetics - administration & dosage Antiemetics - therapeutic use Critical Care Medicine Double-Blind Method Emergency Medicine Female Gastrectomy - adverse effects Gastrectomy - methods Humans Intensive Laparoscopy - adverse effects Laparoscopy - methods Male Medicine Medicine & Public Health Middle Aged Original Article Pain Medicine Postoperative Nausea and Vomiting - prevention & control Prospective Studies Quinuclidines - administration & dosage Quinuclidines - therapeutic use Treatment Outcome |
| title | Study of penehyclidine for the prevention of postoperative nausea and vomiting following laparoscopic sleeve gastrectomy under general anesthesia: a randomized, prospective, double-blind trial |
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