Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study

Current guidance recommends against the use of metformin in people with advanced kidney impairment despite a lack of supporting evidence. The aim of this observational study was to compare outcomes of patients with type 2 diabetes who continued versus stopped metformin after developing stage 4 chron...

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Veröffentlicht in:	American journal of kidney diseases 2024-11
Hauptverfasser:	Lambourg, Emilie J., Fu, Edouard L., McGurnaghan, Stuart, Conway, Bryan R., Dhaun, Neeraj, Grant, Christopher H., Pearson, Ewan R., Mark, Patrick B., Petrie, John, Colhoun, Helen, Bell, Samira, McCrimmon, Rory, Armstrong, Catherine, Emslie-Smith, Alistair, Lindsay, Robert, MacRury, Sandra, McKnight, John, Pearson, Donald, McKinstry, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	chronic kidney disease diabetes epidemiology metformin target trial emulation
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Current guidance recommends against the use of metformin in people with advanced kidney impairment despite a lack of supporting evidence. The aim of this observational study was to compare outcomes of patients with type 2 diabetes who continued versus stopped metformin after developing stage 4 chronic kidney disease (CKD) (eGFR
ISSN:	0272-6386 1523-6838 1523-6838
DOI:	10.1053/j.ajkd.2024.08.012