Tiny but mighty: small molecules as vaccine adjuvants
Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully res...
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| Veröffentlicht in: | Trends in pharmacological sciences (Regular ed.) 2024-12, Vol.45 (12), p.1097-1099 |
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| container_issue | 12 |
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| container_title | Trends in pharmacological sciences (Regular ed.) |
| container_volume | 45 |
| creator | Joffe, Ari Vázquez-Maldonado, Nancy Singleton, Kentner L. Leitner, Wolfgang W. |
| description | Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice.
Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice. |
| doi_str_mv | 10.1016/j.tips.2024.10.011 |
| format | Article |
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Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice.</description><identifier>ISSN: 0165-6147</identifier><identifier>ISSN: 1873-3735</identifier><identifier>EISSN: 1873-3735</identifier><identifier>DOI: 10.1016/j.tips.2024.10.011</identifier><identifier>PMID: 39521663</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - pharmacology ; Adjuvants, Vaccine - pharmacology ; Animals ; High-Throughput Screening Assays ; Humans ; Mice ; Small Molecule Libraries - pharmacology ; structure–activity relationship ; TLR7/8 ; Toll-Like Receptor 7 - agonists ; Toll-Like Receptor 8 - agonists ; vaccine adjuvant</subject><ispartof>Trends in pharmacological sciences (Regular ed.), 2024-12, Vol.45 (12), p.1097-1099</ispartof><rights>2024</rights><rights>Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1523-9e968f772d1f0dbecb3c212f9eae5379e8dd6fb53ebfb69377000a3a7f69b0933</cites><orcidid>0000-0003-3125-5922</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tips.2024.10.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39521663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joffe, Ari</creatorcontrib><creatorcontrib>Vázquez-Maldonado, Nancy</creatorcontrib><creatorcontrib>Singleton, Kentner L.</creatorcontrib><creatorcontrib>Leitner, Wolfgang W.</creatorcontrib><title>Tiny but mighty: small molecules as vaccine adjuvants</title><title>Trends in pharmacological sciences (Regular ed.)</title><addtitle>Trends Pharmacol Sci</addtitle><description>Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice.
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| subjects | Adjuvants, Immunologic - pharmacology Adjuvants, Vaccine - pharmacology Animals High-Throughput Screening Assays Humans Mice Small Molecule Libraries - pharmacology structure–activity relationship TLR7/8 Toll-Like Receptor 7 - agonists Toll-Like Receptor 8 - agonists vaccine adjuvant |
| title | Tiny but mighty: small molecules as vaccine adjuvants |
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