Tiny but mighty: small molecules as vaccine adjuvants

Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully res...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2024-12, Vol.45 (12), p.1097-1099
Hauptverfasser:	Joffe, Ari, Vázquez-Maldonado, Nancy, Singleton, Kentner L., Leitner, Wolfgang W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Adjuvants, Vaccine - pharmacology Animals High-Throughput Screening Assays Humans Mice Small Molecule Libraries - pharmacology structure–activity relationship TLR7/8 Toll-Like Receptor 7 - agonists Toll-Like Receptor 8 - agonists vaccine adjuvant
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Beschreibung
Zusammenfassung:	Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice. Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice.
ISSN:	0165-6147 1873-3735 1873-3735
DOI:	10.1016/j.tips.2024.10.011