Clinical profile of herpes zoster-related hospitalizations and complications: A French population-based database study

To estimate the incidence of hospitalization with a diagnosis of herpes zoster (HZ) and post-herpetic neuralgia (PHN) in France between 2013 and 2020, overall and stratified by age-group and immune status. Retrospective observational, database study, using the French hospital discharge database, whi...

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Veröffentlicht in:The Journal of infection 2024-12, Vol.89 (6), p.106330, Article 106330
Hauptverfasser: Loubet, Paul, Roustand, Laetitia, Schmidt, Aurélie, Jacquemet, Pandora, de Wazières, Benoît, Vabre, Clémentine, Nishimwe, Marie, Faure, Emmanuel
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Sprache:eng
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Zusammenfassung:To estimate the incidence of hospitalization with a diagnosis of herpes zoster (HZ) and post-herpetic neuralgia (PHN) in France between 2013 and 2020, overall and stratified by age-group and immune status. Retrospective observational, database study, using the French hospital discharge database, which includes private and public data for all day-care and inpatient stays. Adults aged ≥18 years, hospitalized between January 1, 2013, and December 31, 2020, with a diagnosis of HZ or PHN, were included. Overall, 62 077 adults had a first hospitalization with a diagnosis of HZ or PHN during the observation period. HZ and/or PHN incidence ranged between 14.6 and 16.3 hospitalizations/100 000 persons and was highest in people aged ≥80 years (97.6 hospitalizations/100 000 persons). The immunocompromised (IC) population accounted for 22% of the overall study population. IC patients had longer lengths of stay for HZ per episode compared with non-IC patients (15.5 ± 19.4 days vs 12.2 ± 13.5 days) and higher in-patient mortality (8% vs 4%). Average annual hospitalization costs per patient were higher in the IC vs non-IC population (€8018 vs €5603). Older age increases hospitalization rates up to 6-fold and IC status increases in-patient mortality up to two-fold. The study was conducted by HEVA and data were provided by ATIH according to French regulatory and data protection procedures. •Retrospective, medico-economic analysis using the French hospital database.•Between 2013 and 2020, 62 077 adults were hospitalized with herpes zoster or PHN.•22% of hospitalized people were immunocompromised (IC) and have prolonged stay.•Risk of in-hospital death was higher in the IC vs non-IC population (8% vs 4%).•Mean annual cost per patient was higher in IC vs non-IC population (€8018 vs €5603).
ISSN:0163-4453
1532-2742
1532-2742
DOI:10.1016/j.jinf.2024.106330