Rapid viral suppression using integrase inhibitors during acute HIV-1 infection

Antiretroviral therapy (ART) is recommended for all individuals with HIV infection, including those with acute HIV-1 infection (AHI). While recommendations are similar to those for chronic infection, efficacy data regarding treatment of acute HIV is limited. This was a single arm, 96-week study of a...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2025-01, Vol.80 (1), p.169-174
Hauptverfasser:	McKellar, Mehri S, Keys, Jessica R, Filiatreau, Lindsey M, McGee, Kara S, Kuruc, Joann D, Ferrari, Guido, Margolis, David M, Eron, Joseph J, Hicks, Charles B, Gay, Cynthia L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - therapeutic use Female HIV Infections - drug therapy HIV Infections - virology HIV Integrase Inhibitors - therapeutic use HIV-1 - drug effects Humans Male Middle Aged Original Research Quinolones RNA, Viral - blood Treatment Outcome Viral Load - drug effects
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Zusammenfassung:	Antiretroviral therapy (ART) is recommended for all individuals with HIV infection, including those with acute HIV-1 infection (AHI). While recommendations are similar to those for chronic infection, efficacy data regarding treatment of acute HIV is limited. This was a single arm, 96-week study of a once-daily integrase inhibitor (INSTI)-based regimen using elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (EVG/COBI/FTC/TDF) in AHI. Primary endpoint was proportion of participants with HIV-1 RNA
ISSN:	0305-7453 1460-2091 1460-2091
DOI:	10.1093/jac/dkae391