Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms

We used single-soma deep RNA sequencing to generate a high-resolution atlas of human somatosensory dorsal root ganglion neurons. This work revealed human-specific molecular features, pain-sensing neuron types, properties of sensory fibers, and potential therapeutic targets, which inform understanding of human somatosensory mechanisms and could facilitate improved success in translational research.