Validation and next-generation update of a DNA methylation-based recurrence predictor for meningioma: a multicenter prospective study

We previously developed a DNA methylation-based risk predictor for meningioma, which has been used locally in a prospective fashion since its original publication. As a follow-up, we validate this model using a large prospective cohort and introduce a streamlined next-generation predictor compatible...

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Veröffentlicht in:Neuro-oncology (Charlottesville, Va.) Va.), 2024-11
Hauptverfasser: Landry, Alexander P, Wang, Justin Z, Patil, Vikas, Gui, Chloe, Yasin, Mamatjan, Patel, Zeel, Yakubov, Rebecca, Kaloti, Ramneet, Habibi, Parnian, Wilson, Mark, Ajisebutu, Andrew, Ellenbogen, Yosef, Wei, Qingxia, Singh, Olivia, Sosa, Julio, Mansouri, Sheila, Wilson, Christopher, Cohen-Gadol, Aaron A, Virtanen, Piiamaria, Burket, Noah, Blackwell, Matthew, Koenig, Jenna, Alfonso, Anthony, Davis, Joseph, Zaazoue, Mohamed A, Tabatabai, Ghazaleh, Tatagiba, Marcos, Behling, Felix, Barnholtz-Sloan, Jill S, Sloan, Andrew E, Chotai, Silky, Chambless, Lola B, Mansouri, Alireza, Ehret, Felix, Capper, David, Tsang, Derek S, Aldape, Kenneth, Gao, Andrew, Nassiri, Farshad, Zadeh, Gelareh
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Sprache:eng
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Zusammenfassung:We previously developed a DNA methylation-based risk predictor for meningioma, which has been used locally in a prospective fashion since its original publication. As a follow-up, we validate this model using a large prospective cohort and introduce a streamlined next-generation predictor compatible with newer methylation arrays. Genome-wide methylation profiles were generated with the Illumina EPICArray. The performance of our next-generation predictor was compared with our original model and standard-of-care 2021 WHO grade using time-dependent receiver operating characteristic curves. An nomogram was generated by incorporating our methylation predictor with WHO grade and extent of resection. A total of 1347 meningioma cases were utilized in the study, including 469 prospective cases from 3 institutions and an external cohort of 100 WHO grade 2 cases for model validation. Both the original and next-generation models significantly outperform 2021 WHO grade in predicting early postoperative recurrence. Dichotomizing patients into grade-specific risk subgroups was predictive of outcome within both WHO grades 1 and 2 tumours (p
ISSN:1522-8517
1523-5866
1523-5866
DOI:10.1093/neuonc/noae236