Positive association of the thigh muscle thickness to intracellular-water ratio with handgrip strength, but not with the risk of mortality in hospitalized cancer patients: a longitudinal study

This study explored the relationship between handgrip strength, muscle thickness, and the intracellular water ratio (MT/ICW) in cancer patients. It aimed to identify a cut-off point for the MT/ICW ratio that might influence survival. Conducted as an exploratory, longitudinal study in a public hospit...

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Veröffentlicht in:European journal of clinical nutrition 2024-11
Hauptverfasser: Gomes, Tatyanne L N, Ivo, Jessica F M, Mainardi, Lara G, Pimentel, Gustavo D
Format: Artikel
Sprache:eng
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Zusammenfassung:This study explored the relationship between handgrip strength, muscle thickness, and the intracellular water ratio (MT/ICW) in cancer patients. It aimed to identify a cut-off point for the MT/ICW ratio that might influence survival. Conducted as an exploratory, longitudinal study in a public hospital, it included patients from 2018 to 2022, with follow-up until August 31, 2023. The cut-off for the MT/ICW ratio was determined based on its sensitivity for mortality. Results indicated that patients with an MT/ICW ratio >0.97 had significantly lower extracellular water percentages and greater muscle thickness. A positive association was found between the MT/ICW ratio and handgrip strength, even after adjusting for age, sex, extracellular water, and body mass index. However, patients with an MT/ICW ratio ≤0.97 showed no significant mortality risk. In conclusion, MT/ICW ratio >0.97 mm/L in hospitalized cancer patients was positively associated with handgrip strength, but not risk of mortality.
ISSN:0954-3007
1476-5640
1476-5640
DOI:10.1038/s41430-024-01532-7