Chitosan oligosaccharides: A potential therapeutic agent for inhibiting foam cell formation in atherosclerosis

Foam cell formation is a key hallmark in atherosclerosis and associated cardiovascular diseases (CVDs). The potential anti-atherosclerotic potential of chitosan oligosaccharides (COS) was investigated using oxLDL-treated RAW264.7 murine cells. COS treatment led to a significant inhibition of lipid a...

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Veröffentlicht in:	International journal of biological macromolecules 2024-12, Vol.282 (Pt 4), p.137186, Article 137186
Hauptverfasser:	Le, My Phuong Thi, Marasinghe, Chathuri Kaushalya, Je, Jae-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammation Antioxidant Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - metabolism Chitosan - chemistry Chitosan - pharmacology Chitosan oligosaccharides Cholesterol - metabolism Foam cells Foam Cells - drug effects Foam Cells - metabolism Lipid Metabolism - drug effects Lipoproteins, LDL - metabolism Liver X Receptors - metabolism Mice NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Oligosaccharides - chemistry Oligosaccharides - pharmacology Oxidative Stress - drug effects Oxidized LDL PPAR gamma - metabolism RAW 264.7 Cells Signal Transduction - drug effects
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