Brain Biopsy Revolution: Unveiling the Core Syringe Technique With Clinical Insights

Obtaining a definitive pathological diagnosis from brain tissue sampling was challenging due to the small, nonrepresentative sample. This study introduced a novel syringe technique for brain biopsy aimed at enhancing diagnostic accuracy by obtaining core tissue samples that better represent the targeted tissue. The 10 patients with atypical brain lesions underwent the syringe biopsy. After meticulous preoperative planning with neuronavigation, a minimally invasive approach was used: a 3-cm skin incision and a 14-mm burr hole were created. A modified 3-cc syringe was used to create negative pressure and cannulate the brain tissue. The desired sample size (24 cm³) was obtained by controlling the syringe depth and withdrawal. Medical records were reviewed to assess sample analysis results and any complications. The syringe technique successfully yielded adequate tissue samples in 9 of 10 patients. In 1 case, the desired tissue could not be retrieved and required a microsurgical approach for removal. In all 10 cases, a correct diagnosis was made without significant complications. The preliminary findings suggest that the syringe technique is both safe and effective for obtaining substantial volumes of brain tissue, facilitating accurate pathological evaluation in cases of complex neurological disorders.