A strong Dysregulated Myeloid Component in the Epigenetic Landscape of Systemic Sclerosis: An Integrated DNA Methylome and Transcriptome Analysis

Nongenetic factors influence systemic sclerosis (SSc) pathogenesis, underscoring epigenetics as a relevant contributor to the disease. We aimed to unravel DNA methylation abnormalities associated with SSc through an epigenome-wide association study. We analyzed DNA methylation data from whole-blood...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2024-12
Hauptverfasser:	Martínez-López, Javier, Ortiz-Fernandez, Lourdes, Estupiñán-Moreno, Elkyn, Kerick, Martin, Andrés-León, Eduardo, Terron-Camero, Laura C, Carnero-Montoro, Elena, Barturen, Guillermo, Beretta, Lorenzo, Almeida, Isabel, Alarcón-Riquelme, Marta E, Ballestar, Esteban, Acosta-Herrera, Marialbert, Martín, Javier
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Nongenetic factors influence systemic sclerosis (SSc) pathogenesis, underscoring epigenetics as a relevant contributor to the disease. We aimed to unravel DNA methylation abnormalities associated with SSc through an epigenome-wide association study. We analyzed DNA methylation data from whole-blood samples in 179 patients with SSc and 241 unaffected individuals to identify differentially methylated positions (DMPs) with a false discovery rate (FDR)
ISSN:	2326-5191 2326-5205 2326-5205
DOI:	10.1002/art.43044