Initial anticoagulation therapy with single direct oral anticoagulant in patients with intermediate-high risk acute pulmonary embolism: From the COMMAND VTE Registry-2

[Display omitted] •Initial single DOAC therapy could be a treatment option for acute PE.•However, the efficacy and safety for intermediate-high risk acute PE is uncertain.•In the real-world registry, 20 % of patients were treated with single DOAC therapy.•There were no signal of worse outcomes compa...

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Veröffentlicht in:	International journal of cardiology 2025-01, Vol.419, p.132680, Article 132680
Hauptverfasser:	Shigeno, Ryo, Kim, Kitae, Yamashita, Yugo, Morimoto, Takeshi, Chatani, Ryuki, Kaneda, Kazuhisa, Nishimoto, Yuji, Ikeda, Nobutaka, Kobayashi, Yohei, Ikeda, Satoshi, Inoko, Moriaki, Takase, Toru, Tsuji, Shuhei, Oi, Maki, Takada, Takuma, Otsui, Kazunori, Sakamoto, Jiro, Ogihara, Yoshito, Inoue, Takeshi, Usami, Shunsuke, Chen, Po-Min, Togi, Kiyonori, Koitabashi, Norimichi, Hiramori, Seiichi, Doi, Kosuke, Mabuchi, Hiroshi, Tsuyuki, Yoshiaki, Murata, Koichiro, Takabayashi, Kensuke, Nakai, Hisato, Sueta, Daisuke, Shioyama, Wataru, Dohke, Tomohiro, Nishikawa, Ryusuke, Furukawa, Yutaka, Kimura, Takeshi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Zusammenfassung:	[Display omitted] •Initial single DOAC therapy could be a treatment option for acute PE.•However, the efficacy and safety for intermediate-high risk acute PE is uncertain.•In the real-world registry, 20 % of patients were treated with single DOAC therapy.•There were no signal of worse outcomes compared with initial parenteral therapy.
ISSN:	0167-5273 1874-1754 1874-1754
DOI:	10.1016/j.ijcard.2024.132680