Coronary CT angiography-based FFR with ultrahigh-resolution photon-counting detector CT: Intra-individual comparison to energy-integrating detector CT

[Display omitted] •There is a lack of data regarding the effect of ultrahigh-resolution PCD-CT on CT-FFR.•An intra-individual comparison of CT-FFR values was conducted between PCD-CT and EID-CT.•Strong correlation and high agreement were noted between EID-CT and PCD-CT-based FFR.•PCD-CT produced hig...

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Veröffentlicht in:European journal of radiology 2024-12, Vol.181, p.111797, Article 111797
Hauptverfasser: Vecsey-Nagy, Milan, Tremamunno, Giuseppe, Schoepf, U. Joseph, Gnasso, Chiara, Zsarnóczay, Emese, Fink, Nicola, Kravchenko, Dmitrij, Taha Hagar, Muhammad, Halfmann, Moritz C., Jokkel, Zsófia, O’Doherty, Jim, Szilveszter, Bálint, Maurovich-Horvat, Pál, Spruill Suranyi, Pal, Varga-Szemes, Akos, Emrich, Tilman
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Sprache:eng
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Zusammenfassung:[Display omitted] •There is a lack of data regarding the effect of ultrahigh-resolution PCD-CT on CT-FFR.•An intra-individual comparison of CT-FFR values was conducted between PCD-CT and EID-CT.•Strong correlation and high agreement were noted between EID-CT and PCD-CT-based FFR.•PCD-CT produced higher CT-FFR values, leading to hemodynamic reclassification in some. To evaluate the feasibility of CT angiography-derived fractional flow reserve (CT-FFR) calculations on ultrahigh-resolution (UHR) photon-counting detector (PCD)-CT series and to intra-individually compare the results with energy-integrating (EID)-CT measurements. Prospective patients with calcified plaques detected on EID-CT between April 1st, 2023 and January 31st, 2024 were recruited for a UHR CCTA on PCD-CT within 30 days. PCD-CT was performed using the same or a lower CT dose index and an equivalent volume of contrast media. An on-site machine learning algorithm was used to obtain CT-FFR values on a per-vessel and per-patient basis. For all analyses, CT-FFR values ≤ 0.80 were deemed to be hemodynamically significant. A total of 34 patients (age: 67.3 ± 6.6 years, 7 women [20.6 %]) were included. Excellent inter-scanner agreement was noted for CT-FFR values in the per-vessel (ICC: 0.93 [0.90–0.95]) and per-patient (ICC: 0.94 [0.88–0.97]) analysis. PCD-CT-derived CT-FFR values proved to be higher compared to EID-CT values on both vessel (0.58 ± 0.23 vs. 0.55 ± 0.23, p 
ISSN:0720-048X
1872-7727
1872-7727
DOI:10.1016/j.ejrad.2024.111797