Epigenetic associations with kidney disease in individuals of African ancestry with APOL1 high-risk genotypes and Human Immunodeficiency Virus

Epigenetic associations with kidney disease in individuals of African ancestry with APOL1 high-risk genotypes and Human Immunodeficiency Virus

Apolipoprotein L1 (APOL1) high-risk variants are major determinants of chronic kidney disease (CKD) in people of African ancestry. Previous studies have identified epigenetic changes in relation to kidney function and CKD, but not in individuals with APOL1 high-risk genotypes. We conducted an epigen...

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Veröffentlicht in:Nephrology, dialysis, transplantation dialysis, transplantation, 2024-10
Hauptverfasser: Hung, Rachel K Y, Costeira, Ricardo, Chen, Junyu, Schlosser, Pascal, Grundner-Culemann, Franziska, Booth, John W, Sharpe, Claire C, Bramham, Kate, Sun, Yan V, Marconi, Vincent C, Teumer, Alexander, Winkler, Cheryl A, Post, Frank A, Bell, Jordana T
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Sprache:eng
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Zusammenfassung:Apolipoprotein L1 (APOL1) high-risk variants are major determinants of chronic kidney disease (CKD) in people of African ancestry. Previous studies have identified epigenetic changes in relation to kidney function and CKD, but not in individuals with APOL1 high-risk genotypes. We conducted an epigenome-wide analysis of CKD and estimated glomerular filtration rate (eGFR) in in people of African ancestry and APOL1 high-risk genotypes with HIV. DNA methylation profiles from peripheral blood mononuclear cells of 119 individuals with APOL1 high-risk genotypes (mean age 48 years, 49% female, median CD4 count 515 cells/mm3, 90% HIV-1 RNA
ISSN:0931-0509
1460-2385
1460-2385
DOI:10.1093/ndt/gfae237