Development and validation of a new and rapid molecular diagnostic tool based on RT-LAMP for Hepatitis C virus detection at point-of-care

[Display omitted] •HCV underdiagnosis among hard-to-reach population is still of concern.•Our new RT-LAMP system detects HCV RNA directly from lysed serum.•High diagnostic test accuracy: LOD

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Bibliographische Detailangaben
Veröffentlicht in:	Methods (San Diego, Calif.) Calif.), 2024-12, Vol.232, p.43-51
Hauptverfasser:	Arca-Lafuente, Sonia, Yépez-Notario, Cristina, Cea-Callejo, Pablo, Lara-Aguilar, Violeta, Crespo-Bermejo, Celia, Martín-Carbonero, Luz, de los Santos, Ignacio, Briz, Verónica, Madrid, Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	HCV Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis C - blood Hepatitis C - diagnosis Hepatitis C - virology Humans Molecular diagnosis Molecular Diagnostic Techniques - methods Nucleic Acid Amplification Techniques - methods POC Point-of-Care Systems RNA virus RNA, Viral - blood RNA, Viral - genetics RNA, Viral - isolation & purification RT-LAMP Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	[Display omitted] •HCV underdiagnosis among hard-to-reach population is still of concern.•Our new RT-LAMP system detects HCV RNA directly from lysed serum.•High diagnostic test accuracy: LOD
ISSN:	1046-2023 1095-9130 1095-9130
DOI:	10.1016/j.ymeth.2024.10.008