David Garbers' Contributions to Chemotaxis Signaling in Sperm

ABSTRACT This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm‐specific, unique Na+/H+ exchanger that represents a chimera b...

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Veröffentlicht in:	Molecular reproduction and development 2024-10, Vol.91 (10), p.e23774-n/a
Hauptverfasser:	Kaupp, U. B., Kendall, Olivia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Adenylyl Cyclases - metabolism Animals calcium Calcium signalling cAMP Chemotaxis Chemotaxis - physiology Chimeras Cyclic AMP - metabolism History, 20th Century Male Na+/H+ exchanger Na+/H+-exchanging ATPase receptor Sea Urchins - metabolism Signal Transduction - physiology signaling Sodium-Hydrogen Exchangers - history Sodium-Hydrogen Exchangers - metabolism Sperm Spermatozoa - metabolism Spermatozoa - physiology
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Beschreibung
Zusammenfassung:	ABSTRACT This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm‐specific, unique Na+/H+ exchanger that represents a chimera between a solute carrier (SLC) and an ion channel. Finally, we will discuss his contributions to the understanding of cAMP signaling in sperm via soluble adenylyl cyclase (sAC) and its control by Ca2+ ions.
ISSN:	1040-452X 1098-2795 1098-2795
DOI:	10.1002/mrd.23774