Association Between White Blood Cell Counts at Diagnosis and Clinical Outcomes in Venous Thromboembolism　― From the COMMAND VTE Registry-2

Background: White blood cell (WBC) counts were reported to be a risk factor for acute adverse events in patients with venous thromboembolism (VTE). However, there are limited data on VTE patients without active cancer.Methods and Results: The COMMAND VTE Registry-2 was a multicenter study enrolling 5,197 consecutive patients with acute symptomatic VTE. We divided 3,668 patients without active cancer into 4 groups based on WBC count quartiles (Q1–Q4) at diagnosis: Q1, ≤5,899 cells/μL; Q2, 5,900–7,599 cells/μL, Q3, 7,600–9,829 cells/μL; and Q4, ≥9,830 cells/μL. Patients in Q4 more often presented with pulmonary embolism (PE) than patients in Q1, Q2, and Q3 (68% vs. 37%, 53%, and 61%, respectively; P