Assessing Dietary Creatine Intake in Population Studies: Challenges and Opportunities

Limited data exist for establishing the dietary requirements for creatine in the general population. This paper delineates the challenges linked to estimating creatine intake from a typical diet, and explores opportunities to improve the assessment of population-wide creatine intake. Conducting additional food chemistry studies with creatine as a standard analyte, labeling the creatine content in common foods, generating more diverse data from population-based studies, and validating new biomarkers could facilitate the establishment of nutrient reference values for this conditionally essential nutrient.