Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy

Multifunctional type-I photosensitizers (PSs) for hydrogen sulfide (H2S) detection and photodynamic therapy (PDT) of hypoxia tumors exhibits attractive curative effect but remains a challenging task. Herein, a mitochondria targeted aggregation-induced emission (AIE) photosensitizer TSPy-SS-P was des...

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Veröffentlicht in:Talanta (Oxford) 2025-01, Vol.282, p.127074, Article 127074
Hauptverfasser: Shi, Jizhong, Liang, Manshan, Qiu, Yiting, Zhang, Jin, Wang, Shihua, Fang, Heng, Jiang, Yongsheng, Ye, Xiaoxia, Luo, Yanshu, Huang, Zu-Sheng, Quan, Yun-Yun
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Sprache:eng
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Zusammenfassung:Multifunctional type-I photosensitizers (PSs) for hydrogen sulfide (H2S) detection and photodynamic therapy (PDT) of hypoxia tumors exhibits attractive curative effect but remains a challenging task. Herein, a mitochondria targeted aggregation-induced emission (AIE) photosensitizer TSPy-SS-P was designed and synthesized, which could be used for H2S detection and simultaneously type I and type II PDT. TSPy-SS-P had excellent selectivity and anti-interference abilities for endogenous and exogenous H2S detection in tumor cells. TSPy-SS-P was able to distinguish tumor cells with high level of H2S from normal cells by fluorescence “turn off” response to H2S. In addition, TSPy-SS-P showed type Ⅰ and type Ⅱ reactive oxygen species (ROS) generation ability to effectively ablate hypoxic tumor cells. TSPy-SS-P showed mitochondria targeting capacity which could produce ROS in situ to disrupt mitochondria and promote cell apoptosis. In vivo PDT experiments showcased that TSPy-SS-P had excellent tumor retention capability, effective tumor ablation ability and good biocompatibility. This work provided a two-pronged strategy to design organelles targeted photosensitizers for H2S detection and effective PDT of tumors. [Display omitted] •A mitochondria targeted AIE photosensitizer TSPy-SS-P was synthesized.•TSPy-SS-P was used for H2S detection and simultaneously type I and type II PDT.•TSPy-SS-P was able to distinguish tumor cells from normal cells.•TSPy-SS-P was able to effectively ablate hypoxic tumor cells.•TSPy-SS-P had excellent in vivo tumor ablation ability and good biocompatibility.
ISSN:0039-9140
1873-3573
1873-3573
DOI:10.1016/j.talanta.2024.127074