Applications of Clauson‐Kaas Reaction in Organic Synthesis

Pyrrole‐embedded organic molecules received a considerable importance due to their numerous biological and material applications. Hence, several synthetic strategies have been devised for the construction of diverse pyrrole analogues over the years. Among these, the Clauson‐Kaas reaction is one of the most widely used protocols for the synthesis of various N‐substituted pyrroles. This review briefly describes the Clauson‐Kaas reaction along with modifications and a detailed account on its applications in the various sectors of organic synthesis. This review provides an overview on the Clauson‐Kaas reaction, its mechanistic pathway, and synthetic modifications for the construction of a wide range of N‐substituted pyrroles. Furthermore, it also elaborates the synthetic usage of Clauson‐Kaas protocol in the synthesis of diverse biologically important heterocyclic scaffolds.