Evolution and Prognostic Impact of Left Ventricular Myocardial Work Indices After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis

ABSTRACT Purpose Left ventricular myocardial work (LVMW) has been shown to better characterize LV function in patients with severe aortic stenosis by correcting LV afterload. The aim of this study was to evaluate the evolution in LVMW indices after transcatheter aortic valve replacement (TAVR) and t...

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Veröffentlicht in:	Echocardiography (Mount Kisco, N.Y.) N.Y.), 2024-10, Vol.41 (10), p.e70006-n/a
Hauptverfasser:	Wu, Hoi W., Fortuni, Federico, Muzafarova, Tamilla, Sarrazyn, Camille, Lopez Santi, Pilar, Chua, Aileen P. A., Butcher, Steele C., Kley, Frank, Weger, Arend, Jukema, J. Wouter, Bax, Jeroen J., Ajmone Marsan, Nina
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over aortic stenosis Aortic Valve Stenosis - complications Aortic Valve Stenosis - physiopathology Aortic Valve Stenosis - surgery Echocardiography - methods Female Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Male myocardial work indices Prognosis Severity of Illness Index Stroke Volume - physiology Transcatheter Aortic Valve Replacement - methods Treatment Outcome Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - physiology
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Zusammenfassung:	ABSTRACT Purpose Left ventricular myocardial work (LVMW) has been shown to better characterize LV function in patients with severe aortic stenosis by correcting LV afterload. The aim of this study was to evaluate the evolution in LVMW indices after transcatheter aortic valve replacement (TAVR) and their prognostic value. Methods The following LVMW indices were calculated before and immediately after TAVR in 255 patients (median age 82 years, 51% male): global work index (GWI), global constructive work (GCW), global wasted work (GWW) and global work efficiency (GWE). The study endpoint was all‐cause mortality. Results After TAVR, LV ejection fraction and LV global longitudinal strain (GLS) did not change significantly (from 56% to 55%, p = 0.470 and from 13.6% to 13.2%, p = 0.068). Concerning LVMW indices, while LV GWW remained unchanged after TAVR (from 247 to 258 mmHg%, p = 0.080), LV GWI, LV GCW, and LV GWE significantly decreased (from 1882 to 1291 mmHg%, p
ISSN:	0742-2822 1540-8175 1540-8175
DOI:	10.1111/echo.70006