Gelatinous transformation of bone marrow associated with ring sideroblasts: A diagnostic pitfall

Gelatinous bone marrow transformation (GBMT) is a rare condition characterized by adipocyte atrophy, deposition of extracellular gelatinous substance in the bone marrow and associated hypoplastic hematopoiesis. The underlying pathogenic mechanisms of GBMT remain poorly understood. Here we describe 3...

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Veröffentlicht in:	Annals of diagnostic pathology 2024-12, Vol.73, p.152385, Article 152385
Hauptverfasser:	Hussain, Mahreen, Rawas, Faisal, Gosnell, Joseph, Medeiros, Leonard J., Lyapichev, Kirill A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anemia, Sideroblastic - diagnosis Anemia, Sideroblastic - pathology Bone Marrow - pathology Bone Marrow Diseases - diagnosis Bone Marrow Diseases - pathology Diagnosis, Differential Female GBMT Gelatinous Humans Male Middle Aged Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - pathology Ring-sideroblasts
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Zusammenfassung:	Gelatinous bone marrow transformation (GBMT) is a rare condition characterized by adipocyte atrophy, deposition of extracellular gelatinous substance in the bone marrow and associated hypoplastic hematopoiesis. The underlying pathogenic mechanisms of GBMT remain poorly understood. Here we describe 3 cases of GBMT associated with ring sideroblasts. An electronic search of institutional archives was conducted via the laboratory information system to identify patients with a body mass index (BMI) of
ISSN:	1092-9134 1532-8198 1532-8198
DOI:	10.1016/j.anndiagpath.2024.152385