Genetic-epigenetic-neuropeptide associations in mood and anxiety disorders: Toward personalized medicine

Mood and anxiety disorders are complex psychiatric conditions shaped by the multifactorial interplay of genetic, epigenetic, and neuropeptide factors. This review aims to elucidate the intricate interactions among these factors and their potential in advancing personalized medicine. We examine the genetic underpinnings, emphasizing key heritability studies and specific gene associations. The role of epigenetics is discussed, focusing on how environmental factors can modify gene expression and contribute to these disorders. Neuropeptides, including substance P, CRF, AVP, NPY, galanin, and kisspeptin, are evaluated for their involvement in mood regulation and their potential as therapeutic targets. Additionally, we address the emerging role of the gut microbiome in modulating neuropeptide activity and its connection to mood disorders. This review integrates findings from genetic, epigenetic, and neuropeptide research, offering a comprehensive overview of their collective impact on mood and anxiety disorders. By highlighting novel insights and potential clinical applications, we underscore the importance of a multi-omics approach in developing personalized treatment strategies. Future research directions are proposed to address existing knowledge gaps and translate these findings into clinical practice. Our review provides a fresh perspective on the pathophysiology of mood and anxiety disorders, paving the way for more effective and individualized therapies. •Neuropeptides are crucial in gene expression, synaptogenesis, and emotional regulation.•They are involved in stress responses and adjustments, impacting anxiety and depression.•Genetic studies have identified loci related to psychiatric disorders, suggesting shared etiological pathways.•Epigenetic mechanisms, such as microRNAs and histone acetylation, influence antidepressant effectiveness.•Targeting neuropeptide systems and genetic factors shows promise in treating stress-related psychiatric disorders.