Structural characteristics, biological activities and market applications of Rehmannia Radix polysaccharides: A review

Rehmannia Radix Polysaccharides (RRPs) are biopolymers that are isolated and purified from the roots of Rehmannia glutinosa Libosch, which have attracted considerable attention because of their biological activities, such as anti-inflammatory, antioxidant, immunomodulatory, anti-tumor, hypoglycaemic etc. In this manuscript, the composition and structural characteristics of RRPs are reviewed. Moreover, the research progress on the conformational relationships and biological activities of RRPs is systematically summarized. Additionally, this manuscript also analyzes 155 patents using RRPs as the main raw materials to explore the status quo and bottleneck for the development and utilization of RRPs. In summary, this review not only provides a theoretical basis for future research on RRPs but also provides clear guidance for their market applications and innovation. [Display omitted] •Recent advancements in structural features of Rehmannia Radix Polysaccharides were summarized.•The relationships between chemical structures and bioactivity of Rehmannia Radix Polysaccharide were discussed.•The effect of processing on the structure and activity of Rehmannia Radix Polysaccharides were also discussed•The potential for development of Rehmannia Radix Polysaccharides as a drug or dietary supplement were evaluated.