Decreased Nuclear Immunoexpression of ING3 is a Frequent Event in Lip Carcinogenesis

Purpose Evaluate the immunohistochemical expression of the ING3 in actinic cheilitis and squamous cell carcinoma of the lower lip. Methods Forty-five specimens of actinic cheilitis and 48 specimens of squamous cell carcinoma of the lower lip were submitted to immunohistochemical detection of ING3. T...

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Veröffentlicht in:	Head & neck pathology (Totowa, N.J.) N.J.), 2024-10, Vol.18 (1), p.103, Article 103
Hauptverfasser:	de Barros, Joyce Magalhães, de Farias Morais, Hannah Gil, de Oliveira Costa, Carla Samily, Rolim, Larissa Santos Amaral, de Sousa Lopes, Maria Luiza Diniz, Guedes Queiroz, Lélia Maria, de Souza, Lélia Batista, Pinto, Leão Pereira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Carcinogenesis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Nucleus - metabolism Cell Nucleus - pathology Cheilitis - metabolism Cheilitis - pathology Dentistry Female Homeodomain Proteins - biosynthesis Homeodomain Proteins - metabolism Humans Immunohistochemistry Lip Neoplasms - metabolism Lip Neoplasms - pathology Male Medicine Medicine & Public Health Middle Aged Oral and Maxillofacial Surgery Otorhinolaryngology Pathology Squamous Cell Carcinoma of Head and Neck - metabolism Squamous Cell Carcinoma of Head and Neck - pathology Tumor Suppressor Proteins - biosynthesis
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Zusammenfassung:	Purpose Evaluate the immunohistochemical expression of the ING3 in actinic cheilitis and squamous cell carcinoma of the lower lip. Methods Forty-five specimens of actinic cheilitis and 48 specimens of squamous cell carcinoma of the lower lip were submitted to immunohistochemical detection of ING3. The protein expression in different cellular sublocations was compared between the two groups, and associations with the clinicopathological variables were analyzed. A significance level of 5% was adopted for all tests. Results Deaths were significantly more frequent in tumors with a high histopathological risk score ( p
ISSN:	1936-0568 1936-0568
DOI:	10.1007/s12105-024-01683-w