MICUs protect the heart by regulating mitochondrial calcium

Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in c...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2024-11, Vol.45 (11), p.950-952
Hauptverfasser:	Ozkurede, Ulas, Pakkiriswami, Shanmugasundaram, Liu, Julia C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals calcium Calcium - metabolism Calcium Channels - metabolism Calcium-Binding Proteins - metabolism Cation Transport Proteins - metabolism EMRE heart Heart Diseases - metabolism Heart Diseases - prevention & control Humans MCU MICU1 MICU2 mitochondria Mitochondria, Heart - metabolism Mitochondrial Membrane Transport Proteins - metabolism
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Zusammenfassung:	Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease. Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease.
ISSN:	0165-6147 1873-3735 1873-3735
DOI:	10.1016/j.tips.2024.09.010