Enantioselective Synthesis of 3‐Hydroxy‐2‐Oxindoles via Ni‐Catalyzed Asymmetric Addition of Aromatic Bromides to α‐Ketoamides

Nickel‐catalyzed asymmetric intramolecular addition of aryl halides to α‐ketoamides has been achieved to afford chiral 3‐substituted‐3‐hydroxy‐2‐oxindoles in excellent yields and high enantioselectivities (up to 99 % yield and 98 % ee), which provides efficient access to valuable molecules containin...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemistry : a European journal 2024-12, Vol.30 (72), p.e202403622-n/a
Hauptverfasser:	Tian, Jiangyan, Li, Xuening, Shou, Tao, Li, Wendian, Lv, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric addition Asymmetry Bromides Chemical synthesis Enantiomers Halides Hydroxyl oxindole Ketoamides Nickel Reductive coupling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!