Enantioselective Synthesis of 3‐Hydroxy‐2‐Oxindoles via Ni‐Catalyzed Asymmetric Addition of Aromatic Bromides to α‐Ketoamides

Nickel‐catalyzed asymmetric intramolecular addition of aryl halides to α‐ketoamides has been achieved to afford chiral 3‐substituted‐3‐hydroxy‐2‐oxindoles in excellent yields and high enantioselectivities (up to 99 % yield and 98 % ee), which provides efficient access to valuable molecules containing 3‐hydroxy‐2‐oxindole core. The gram‐scale reaction proved the potential utility of the methodology. Nickel‐catalyzed asymmetric intramolecular addition of aryl halides to α‐ketoamides has been achieved to yield chiral 3‐substituted‐3‐hydroxy‐2‐oxindoles in excellent yields and high enantioselectivities (up to 99 % yield and 98 % ee), which provides efficient access to valuable molecules containing 3‐hydroxy‐2‐oxindole core.