Oxidative Amidation of Ferrocenyl Aldehydes with Amines Catalyzed by Chalcogenised Fe3Se2(CO)9 Cluster: Direct Transformation of Aldehyde to Amides

With the interest and knowing the importance of ferrocenyl conjugates, a direct amidation of ferrocenyl aldehyde has been developed under feasible conditions. Varieties of amines has been oxidatively coupled with ferrocene aldehyde in the presence of highly economical and robustly stable iron chalcogenide ironcarbonyl clusters [Fe3E2(CO)9, E= S, Se, and Te] and TBHP. The reaction worked in greener solvent water at a moderate temperature of 70 °C and the ferrocenyl‐amides in just 30 minutes. All the varieties of amines were found to be well tolerated for the present method, and due to the high medicinal importance of ferrocenyl‐amides, sole focus of this report was concentrates on the synthesis of various new ferrocenyl‐amides in good to excellent amounts. Direct formation of ferrocenyl amide have been developed by oxidative amidation reaction of ferrocenyl aldehyde and amines. The reaction works in green solvent water and use an economical iron carbonyl as catalyst. Methods equally works for aryl/alkyl aldehyde and produces good to excellent transformation of the desired amide product.