Propargyl alcohol as an acrolein equivalent: synthesis of β-(3-indolyl)acroleins and β-(imidazo[1,2- a ]pyridin-3-yl)acroleins

A simple and straightforward method has been developed to access distinctly substituted β-(3-indolyl)acroleins and β-(imidazo[1,2- ]pyridin-3-yl)acroleins using propargyl alcohol as an acrolein equivalent. A broad substrate scope, good yields, easily accessible substrates, and metal-free conditions...

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Veröffentlicht in:Organic & biomolecular chemistry 2024-11, Vol.22 (44), p.8720-8723
Hauptverfasser: Bhawani, Sonam, Shinde, Vikki N, Swami, Prakash N, Rangan, Krishnan, Kumar, Anil
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Sprache:eng
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Zusammenfassung:A simple and straightforward method has been developed to access distinctly substituted β-(3-indolyl)acroleins and β-(imidazo[1,2- ]pyridin-3-yl)acroleins using propargyl alcohol as an acrolein equivalent. A broad substrate scope, good yields, easily accessible substrates, and metal-free conditions are the salient features of the developed methodology. This work contributes to a significant advancement in the sustainable synthesis of functionalized acroleins.
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/d4ob01168f