Propargyl alcohol as an acrolein equivalent: synthesis of β-(3-indolyl)acroleins and β-(imidazo[1,2- a ]pyridin-3-yl)acroleins
A simple and straightforward method has been developed to access distinctly substituted β-(3-indolyl)acroleins and β-(imidazo[1,2- ]pyridin-3-yl)acroleins using propargyl alcohol as an acrolein equivalent. A broad substrate scope, good yields, easily accessible substrates, and metal-free conditions...
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Veröffentlicht in: | Organic & biomolecular chemistry 2024-11, Vol.22 (44), p.8720-8723 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A simple and straightforward method has been developed to access distinctly substituted β-(3-indolyl)acroleins and β-(imidazo[1,2-
]pyridin-3-yl)acroleins using propargyl alcohol as an acrolein equivalent. A broad substrate scope, good yields, easily accessible substrates, and metal-free conditions are the salient features of the developed methodology. This work contributes to a significant advancement in the sustainable synthesis of functionalized acroleins. |
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ISSN: | 1477-0520 1477-0539 1477-0539 |
DOI: | 10.1039/d4ob01168f |