Degradation of pathogenic amyloids induced by matrix metalloproteinase-9

Over the past decade, the greatest promise for treating severe and currently incurable systemic and neurodegenerative diseases has turned to agents capable of effectively degrading pathological amyloid deposits without causing side effects. Specifically, amyloid destruction observed in immunotherapy...

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Veröffentlicht in:	International journal of biological macromolecules 2024-11, Vol.281 (Pt 3), p.136362, Article 136362
Hauptverfasser:	Stepanenko, Olga V., Sulatsky, Maksim I., Mikhailova, Ekaterina V., Stepanenko, Olesya V., Sulatskaya, Anna I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Amyloid - chemistry Amyloid - metabolism Amyloid fibril degradation Amyloidosis - metabolism Amyloidosis and neurodegeneration Animals Complex anti-amyloid therapy Degradation product toxicity Extracellular matrix metalloproteinase-9 (MMP9) Humans Matrix Metalloproteinase 9 - metabolism Muramidase - chemistry Muramidase - metabolism Proteolysis
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