Bidirectional causality between micronutrients and mental illness: Mendelian randomization studies

Previous observational clinical research has suggested a link between micronutrients and psychiatric conditions. However, the causal relationship between these nutrients and mental health disorders remains uncertain. This study endeavors to fill this knowledge gap by employing a Mendelian randomization (MR) analysis on pooled data from genome-wide association studies (GWAS), aiming to explore the potential causal associations between 20 prevalent micronutrients and 7 common psychiatric disorders. A collection of single nucleotide polymorphisms (SNPs) associated with 20 micronutrients and seven common psychiatric disorders and extracted from a dataset comprising 7,368,835 individuals. MR analysis, including inverse variance weighting (IVW), Mendelian randomization-egger, weighted median, and sensitivity analysis, was used to evaluate the reliability of the study results. A significance threshold of p