Characterizing Genetic Susceptibility to Colorectal Cancer in Taiwan Through Genome‐Wide Association Study

ABSTRACT We conducted the first genome‐wide association study (GWAS) of colorectal cancer (CRC) in Taiwan with 5342 cases and 61,015 controls. Ninety‐two SNPs in three genomic regions reached genome‐wide significance (p

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Veröffentlicht in:	Molecular carcinogenesis 2025-01, Vol.64 (1), p.25-32
Hauptverfasser:	Bau, Da‐Tian, Liu, Ting‐Yuan, Yang, Jai‐Sing, Chen, William Tzu‐Liang, Tsai, Chia‐Wen, Chang, Wen‐Shin, Ke, Tao‐Wei, Liao, Chi‐Chou, Chen, Yu‐Chia, Chang, Yen‐Ting, Tsai, Fuu‐Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged AUC Biomarkers Cancer therapies Case-Control Studies Cell cycle Chromosome 10 Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA repair E-cadherin Extracellular matrix Female Genetic Predisposition to Disease genetic risk score Genome-wide association studies Genome-Wide Association Study Genomes Humans Male Middle Aged Molecular modelling Polymorphism, Single Nucleotide ROC curve Single-nucleotide polymorphism SNP Susceptibility Taiwan - epidemiology Tumorigenesis
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Zusammenfassung:	ABSTRACT We conducted the first genome‐wide association study (GWAS) of colorectal cancer (CRC) in Taiwan with 5342 cases and 61,015 controls. Ninety‐two SNPs in three genomic regions reached genome‐wide significance (p
ISSN:	0899-1987 1098-2744 1098-2744
DOI:	10.1002/mc.23823